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Completed Trials

Bladder

GU07-123

Phase II Trial of Neoadjuvant Cisplatin, Gemcitabine and Sunitinib Malate Followed by Radical Cystectomy for Transitional Cell Carcinoma (TCC) of the Bladder Read More

GU00-13

A Phase II Study of ALIMTA in Patients With Advanced or Metastatic Transitional Cell Carcinoma of the Urothelium Read More

GU98-2

Weekly Paclitaxel and Gemcitabine in Advanced Transitional Cell Carcinoma of the Urothelium: A Phase II Hoosier Oncology Group Study Read More

GU04-75

A Phase II Trial of Cisplatin, Gemcitabine and Bevacizumab in Combination for Metastatic Transitional Cell Cancer: Hoosier Oncology Group GU04-75
Read More

GU07-122

A Pilot Study of Neoadjuvant Dasatinib Followed by Radical Cystectomy for Transitional Cell Carcinoma of the Bladder Read More

GU12-157

A Phase II Trial of Dovitinib in Bacillus Calmette-Guerin(BCG) Refractory Urothelial Carcinoma Patients With Tumor Fibroblast Growth Factor Receptor 3(FGFR3) Mutations or Over-expression: Hoosier Cancer Research Network GU12-157 Read More

Breast

BRE07-126

A Phase II Study of Lonafarnib in Patients with Locally advanced and Metastatic Breast Cancer: Hoosier Oncology Group: BRE07-126 Read More

BRE94-1

A Hoosier Oncology Group Phase II Study of Biweekly Cisplatin (C) and Paclitaxel (P) in the Treatment of Metastatic Breast Cancer: A Hoosier Oncology Group (HOG) and Walther Cancer Institute Trial BRE94-1 Read More

BRE89-1

Carboplatin and WR-2721 as First-Line Chemotherapy for Metastatic Breast Cancer (MBC): A Hoosier Oncology Group Study BRE89-1 Read More

BRE06-109

A Phase II Study of Combined VEGF Inhibitor (Bevacizumab + Sorafenib) in Patients With Metastatic Breast Cancer: Hoosier Oncology Group Study BRE06-109 Read More

COE-05

A Retrospective Analysis of Proteomic, Genomic, and Pharmacogenetics in Patients Receiving Systemic Chemotherapy for Locally Advanced or Metastatic Breast Cancer Read More

BRE99-1

Phase II Trial of Gemcitabine, Paclitaxel and Trastuzumab in Metastatic Breast Cancer: a Hoosier Oncology Group Trial Read More

BRE98-1

Combined anti-microtubule therapy: A phase II study of weekly docetaxel plus estramustine in patients with metastatic breast cancer, Hoosier Oncology Group BRE98-1 Read More

BRE96-1

Randomized Pilot Trial of Combination Versus Sequential Taxotere (T) and Doxorubicin (D) as Primary Chemotherapy for Breast Cancer Read More

BRE10-150

A Randomized Phase II Study Of Imetelstat (GRN163L) In Combination With Paclitaxel (With Or Without Bevacizumab) in Patients With Locally Recurrent Or Metastatic Breast Cancer Read More

BRE06-117

A Randomized, Double-Blind, Phase 2 Trial of Paclitaxel Plus Bevacizumab and Enzastaurin Versus Paclitaxel Plus Bevacizumab and Placebo for Locally Recurrent or Metastatic Breast Cancer Read More

BRE05-97

A Phase II Study of Oral Enzastaurin in Patients With Metastatic Breast Cancer Previously Treated With an Anthracycline and a Taxane-Containing Regimen Read More

BRE06-120

A Biological Sample Collection Protocol of Women With and Without Breast Cancer: Hoosier Oncology Group Study BRE06-120 for the Analytical Proteomics Team Read More

BRE03-60

A Phase II Trial of Capecitabine and Oxaliplatin (CAPOX) in Patients With Metastatic Breast Cancer: Hoosier Oncology Group BRE03-60 Read More

TBCRC12-142

ABCDE: A Phase II Randomized Study of Adjuvant Bevacizumab, Metronomic Chemotherapy (CM), Diet and Exercise After Preoperative Chemotherapy for Breast Cancer Read More

Colorectal

GI00-2

A Phase II Trial of Irinotecan (CPT-11), 5-Fluorouracil (5-FU), Glutamine, Leucovorin and Celecoxib as First Line Therapy for Metastatic Colorectal Cancer –GI00-2 Read More

GI89-1

A Randomized Phase III Study of 5-Fluorouracil vs 5-Fluorouracil + Levamisole in Previously Untreated Metastatic Colon Cancer – GI89-1 Read More

GI05-102

Phase I / Randomized Phase II Study of Second Line Therapy With Irinotecan and Cetuximab With or Without RAD001, an Oral mTOR Inhibitor for Patients With Metastatic Colorectal Cancer: Hoosier Oncology Group GI05-102 Read More

Endometrial

GYN97-1

A Phase II Study of Intraperitoneal 32p and Vaginal Brachytherapy in the Treatment of Papillary Serous and Clear Cell Adenocarcinoma of the Endometrium Read More

Esophageal

GI00-16

A Phase II Study of Cisplatin, 5-Fluorouracil (5-FU), Radiation Therapy and Celecoxib for Resectable Esophageal Cancer – HOG GI 00-16 Read More

GI06-112

A Phase II Study of Sunitinib Malate (Sutent®) With Paclitaxel (Taxol®) in Patients With Advanced Esophageal Cancer Read More

GI05-92

A Pilot Study With Cetuximab and Radiation Therapy for Patients With Surgically Resectable Esophageal and GE Junction Carcinomas: Hoosier Oncology Group Study (GI05-92) Read More

Head and Neck

HN90-1

Phase II Trial of Interferon Alpha-2b plus Cisplatin and 5-FU in Recurrent or Metastatic Head and Neck Cancer Read More

HN94-1

A Phase II Trial of Ifosfamide in the Treatment of Advanced or Recurrent Squamous Cell Cancer of the Head and Neck Read More

Hepatocellular Carcinoma

GI06-101

Phase II Trial of Erlotinib in Combination With Docetaxel in Advanced Hepatocellular and Biliary Tract Carcinomas: Hoosier Oncology Group GI06-101 Read More

Kidney

GU94-1

A Phase II Trial of Levamisole in the Treatment of Advanced Renal Cell Cancer Read More

GU91-1

A Phase II Study of Altretamine (HEX) for the Treatment of Metastatic Renal Cell Cancer Read More

GU88-1

Phase II Study of Vinblastine + Dipyridamole for Metastatic Renal Cell Carcinoma Read More

GU90-1

Phase II Study of Recombinant Interferon Alpha-2a in Metastatic Renal Cell Cancer Read More

Lung

LUN88-6

Phase II Trial of Daily Oral Etoposide in Advanced Non-Small Cell Lung Cancer Read More

LUN90-1

Phase II Trial of Carboplatin plus Interferon Alpha-2a in Advanced Non-Small Cell Lung Cancer Read More

LUN91-2

A Phase II Trial of CODE + G-CSF in Advanced NSCL Read More

LUN93-4

A Phase II Study of Gemcitabine + Cisplatin in Non-Small Cell Lung Cancer Read More

LUN96-2

A Phase II Study of Carboplatin plus Gemcitabine in Metastatic Non-Small Cell Lung Cancer Read More

LUN96-1

A Phase II Study of Paclitaxel (3-Hour Infusion and Bolus Doxorubicin in Recurrent or Refractory Small Cell Lung Cancer Read More

LUN95-1

A Phase III Study of Gemcitabine +Cisplatin vs Cisplatin Alone in Patients with Metastatic Non-Small Cell Lung Cancer Read More

LUN91-1

A Randomized Phase III Study of Definitive Radiation Therapy with or without Hydroxyurea in Previously Untreated Limited Unresectable Non-Small Cell Lung Cancer Read More

LUN97-1

A Phase II Study of Taxol + Carboplatin + Radiotherapy in Unresectable Stage III Non-Small Cell Lung Cancer Read More

LUN98-1

A Phase II Study of Weekly Paclitaxel Plus Gemcitabine in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer Read More

LUN02-29

A Phase II Trial of ZD1839 (IRESSA®) in Both Patients with Chemosensitive and Chemorefractory Relapsed Neuroendocrine Cancers Read More

LUN02-50

A Phase II Trial of Gefitinib (Iressa®) Plus Celecoxib (Celebrex®) in Chemotherapy-naïve Patients with Stage IIIb/IV Non-Small Cell Lung Cancer (NSCLC) Read More

LUN04-78

Pemetrexed (Alimta) in Patients with Chemosensitive and Chemoresistant Relapsed Small Cell Lung Cancer Read More

LUN08-129

Phase II Study of Concurrent Pemetrexed and Radiation for Stage III Non-Small Cell Lung Cancer Read More

LUN86-1

A Randomized Phase III Study Of Definitive Radiation Therapy With/Without Cisplatinum in Previously Untreated Inoperable Non-Metastatic Non-Small Cell Lung Cancer Read More

LUN93-2

A Phase III Trial of Maintenance Daily Oral VP-16 vs no Further Therapy Following Induction Chemotherapy with VP-16 plus Ifosfamide plus Cisplatin (VIP) in Extensive Small Cell Lung Cancer Read More

LUN01-15

A Phase III Randomized Study of Taxotere 75/mg/M2 vs. ALIMTA for Second-line Chemo for Non-Small Cell Lung Cancer Read More

LUN01-25

Phase Ib/IIa Study of an Anti-Epidermal Growth Factor Receptor (EGFr) Antibody, Cetuximab, in Combination with Carboplatin-Paclitaxel in Patients with Chemo-therapy Naïve Advanced Non Small Cell Lung Cancer Read More

LUN00-12

A Randomized, Phase III Trial Comparing CPT-11/ Cisplatin with Etoposide/Cisplatin in Patients with Previously Untreated, Extensive Small-Cell Lung Cancer Read More

LUN87-1

A Phase II Trial of VP-16, Ifosfamide and Cisplatin (VIP) Combination Chemotherapy for Previously Untreated Extensive Small Cell Lung Cancer Read More

LUN12-152

A Phase 2, Double-Blind, Placebo-Controlled Study of IPI-504 and Docetaxel in Previously Treated Patients With Stage IIIB or IV Non-Small Cell Lung Cancer
Read More

LUN06-116

Protocol H6Q-MC-S034(a) Randomized, Double-Blind, Phase 2 Study of Pemetrexed + Carboplatin + Bevacizumab + Enzastaurin Versus Pemetrexed + Carboplatin + Bevacizumab + Placebo in Chemonaive Patients With Stage IIIB or IV Non-Small Cell Lung Cancer Read More

LUN04-77

A Phase II Study of Erlotinib With Bevacizumab in Chemotherapy Naïve Performance Status (PS) 2 Patients With Advanced Non-Small Cell Lung Cancer Read More

LUN05-99

Paclitaxel Plus Bevacizumab in Patients With Chemosensitive Relapsed Small Cell Lung Cancer (SCLC): A Safety, Feasibility and Efficacy Study
Read More

LUN01-24

A Phase III Trial of Cisplatin/Etoposide/Radiotherapy With or Without Consolidation Docetaxel in Patients With Inoperable Locally Advanced Stage III Non-Small Cell Lung Cancer (NSCLC): Hoosier Oncology Group LUN01-24 Read More

LUN04-79

A Phase I-IIa Dose-Ranging Study of Pemetrexed (Alimta) Plus Cetuximab (Erbitux) in Patients With Recurrent Non-Small Cell Lung Cancer (NSCLC): Hoosier Oncology Group LUN04-79 Read More

LUN07-130

A Phase I Study of Amrubicin and Cyclophosphamide in Patients With Advanced Solid Organ Malignancies
Read More

LUN06-113

A Randomized Double Blind Phase II Trial of Cisplatin Plus Etoposide With/Without Concurrent ZD6474 in Patients With Previously Untreated Extensive Stage Small Cell Lung Cancer: Hoosier Oncology Group LUN06-113

For full description, see www.clinicaltrials.gov.

Abstracts/Posters/Presentations:

  • R.E. Sanborn, J.D. Patel, G.A. Masters, N. Jayaram, A.W. Stephens, M.J. Guarino, J.G. Misleh, C.E. Williams, J.Wu, N.H. Hanna. A randomized double-blind phase II trial of platinum (P) plus etoposide (E) with or without concurrent ZD6474 (Z) in patients (pts) with previously untreated extensive-stage (ES) small cell lung cancer (SCLC): Hoosier Oncology Group LUN06-113. Presented at the oral abstract session, lung cancer – non-small cell local-regional/small cell/other thoracic cancers at the ASCO Annual Meeting, May 30 – June 3, 2014, Chicago IL. J Clin Oncol 32:5s, 2014 (suppl; abstr 7506). See abstract.
  • Sanborn, R. E., Patel, J. D., Masters, G. A., Jayaram, N., Stephens, A., Guarino, M., Misleh, J., Wu, J. and Hanna, N. (2016), A randomized, double-blind, phase 2 trial of platinum therapy plus etoposide with or without concurrent vandetanib (ZD6474) in patients with previously untreated extensive-stage small cell lung cancer: Hoosier Cancer Research Network LUN06-113. Cancer. doi:10.1002/cncr.30287. See abstract.

Lymphoma

NHL00-1

A Phase II Study of Single Agent Gemcitabine In Relapsed or Refractory Follicular or Small Lymphocytic Non-Hodgkin’s Lymphoma Read More

Melanoma

MEL91-1

A Phase III Study Comparing Cisplatin, Dacarbazine, Carmustine and Tamoxifen vs Dacarbazine Alone in Patients with Advanced Melanoma Read More

MEL89-1

Phase II Study of Daily Oral VP-16 in Previously Untreated Melanoma Read More

Mutiple Myeloma

MM01-21

A Phase II Study of Daily Thalidomide, Oral Cytoxan and Prednisone for Relapsed or Refractory Multiple Myeloma Read More

Myelodysplastic Syndromes

MDS98-1

A Phase II Trial of Topotecan in Patients With Myelodysplastic Syndrome Read More

MDS04-85

A Phase II Randomized Trial with a Modified Dose and Schedule of Subcutaneously Administered Azacitidine and Erythropoietin versus Azacitidine Alone in Patients with Low-Risk Myelodysplastic Syndromes (Less than 11% Marrow and Peripheral Blood Blasts) Read More

Ovarian

GYN98-1

A Phase II Trial of Ifosfamide and Oral Etoposide For Refractory Ovarian Cancer Read More

GYN06-111

A Phase I/II Study of Sorafenib in Combination with Topotecan for the Treatment of Platinum-Resistant Recurrent Ovarian Cancer or Primary Peritoneal Carcinomatosis Read More

GYN06-106

A Phase 2, Open-Label, Safety and Efficacy Study of Panzem® Nanocrystal Colloidal Dispersion Administered Orally in Patients With Recurrent or Resistant Epithelial Ovarian Cancer Read More

GYN03-62

Imatinib Mesylate (Gleevec®, STI571) in Combination With Docetaxel (Taxotere) for the Treatment of Advanced, Platinum-Refractory Ovarian Cancer and Primary Peritoneal Carcinomatosis: Hoosier Oncology Group GYN03-62 Read More

GYN10-149

A Phase I-II Clinical Trial of Pegylated Liposomal Doxorubicin (Doxil®) in Combination With BIBF 1120 in Patients With Ovarian Cancer: Hoosier Oncology Group GYN10-149 Read More

Pancreatic

GI89-2

Phase II Study of 5-FU and Leucovorin + Radiation in Pancreatic Cancer Read More

GI99-1

A Phase II Study of Gemcitabine and Docetaxel in Combination for Advanced Pancreatic Cancer Read More

GI00-11

A Phase II Study of Gemcitabine in Combination with Radiation Therapy in Patients with Localized Unresectable Pancreatic Cancer Read More

GI98-1

Phase I/II Study of Gemcitabine and Docetaxel in Combination for Unresectable or Metastatic Pancreatic Cancer – GI98-1 Read More

GI91-1

Phase I/II Study of Weekly Oral MTX + AZT in the Treatment of Metastatic Adenocarcinoma of the Pancreas and Hepatoma – GI91-1 Read More

Prostate

GU02-41

A Phase III, Randomized, Double-Blind, Placebo Controlled Trial Evaluating the Ability of Risedronate to Prevent Skeletal Related Events in Patients with Metastatic Prostate Cancer Commencing Hormonal Therapy Read More

GU00-9

A Multicenter Randomized Phase II Study of Docetaxel plus Vinorelbine and Doxetacel plus Estramustine in Combination for Hormone Refractory Prostate Cancer Read More

GU98-1

Phase II Study of Vinorelbine plus Estramustine in Metastatic Hormone-Refractory Prostate Cancer Read More

GU93-1

A Phase III Study of Vinblastine vs Vinblastine plus Estramustine for Metastatic Hormone Refractory Prostatic Cancer Read More

GU03-67

A Phase II Study of Pemetrexed (Alimta) as Second-Line Therapy for Hormone Refractory Prostate Cancer: Hoosier Oncology Group GU03-67 Read More

Quality of Life

QL03-70

Phase II Trial of Olanzapine (Zyprexa) and Palonosetron (Aloxi) for the Prevention of Chemotherapy Induced Nausea and Vomiting Read More

QL01-26

A Phase II Trial of Olanzapine (Zyprexa) for the Prevention of
Delayed Emesis in Cancer Patients Receiving Chemotherapy
Read More

QL00-4

A Phase I Trial of Olanzapine (Zyprexa) For the Prevention of
Delayed Emesis In Cancer Patients Receiving Chemotherapy
Read More

QL97-1

Fluoxetine Versus Placebo in Advanced Cancer Outpatients: A Randomized, Double-Blind, Placebo-Controlled Trial Read More

QL05-37

Phase III, Double-Blind, Placebo-Controlled, Crossover Study Evaluating Aprepitant in Combination With a 5HT3 & Dexamethasone in Patients With Germ Cell Tumors Undergoing 5 Day Cisplatin-Based Chemotherapy Regimen Read More

QL12-153

Phase II Study of Fosaprepitant + 5HT3 Receptor Antagonists + Dexamethasone in Patients With Germ Cell Tumors Undergoing 5 Day Cisplatin-based Chemotherapy: Hoosier Oncology Group Study QL12-153 Read More

Rectal

GI03-53

A Phase II Trial of Preoperative Capecitabine Plus Irinotecan Followed by Combined Modality Capecitabine and Radiation for Locally Advanced Rectal Cancer – GI03-53 Read More

Sample Collection

BNK09-138

A Biological Sample Collection Protocol of Patients with and without Metastatic Solid Organ Malignancies Read More


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