network member

The Ohio State University

Columbus, Ohio
The Ohio State University

About Network Member

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) strives to create a cancer-free world, one person, one discovery at a time through research that translates to innovative and highly targeted patient care. The OSUCCC – James is the only cancer program in the United States that features a National Cancer Institute (NCI)–designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nation’s largest public universities. At the Forefront of Research The OSUCCC – James is one of only 51 NCI-designated comprehensive cancer centers in the nation, a designation it has maintained through competitive renewal since 1976. After its most recent NCI site review, the cancer center earned the NCI’s highest ranking, “exceptional,” for the third consecutive time and received a five-year NCI cancer center support grant. At Ohio State, more than 330 cancer researchers and their teams from 11 of the university’s 15 colleges work collaboratively across multiple disciplines to improve the effectiveness of cancer prevention, diagnosis and treatment. Each scientist is a member of one of five interdisciplinary research programs: Cancer Control, Translational Therapeutics, Cancer Biology, Molecular Carcinogenesis and Chemoprevention, and Leukemia Research. The OSUCCC – James also recently established a Pelotonia Institute for Immuno-Oncology (PIIO)—a comprehensive bench-to-bedside research initiative focused on harnessing the body’s immune system to fight cancer at all levels, from prevention to treatment and survivorship. The PIIO, which complements the OSUCCC – James’ pursuit of precision cancer medicine-driven therapies, has developed a strategic plan and recruited many scientists and staff members with expertise ranging from development of cancer vaccines to bioinformatic and statistical modeling for high-throughput immunogenomic screening. These scientists have brought the total number of researchers working on immuno-oncology approaches to clinical trials at the OSUCCC – James to over 60. The PIIO plans to open up to 130 immuno-oncology clinical trials over the next five years and to create a pipeline of novel cancer immunotherapeutics, many of them driven by Ohio State discoveries that will be tested at patient bedsides. To guide PIIO research efforts, the institute has organized into four interconnected centers of excellence: Cancer Immuno-Genomics, Cell Therapy, Systems Immuno-Oncology and Translational Immuno-Oncology. Excellence in Cancer Care The James Cancer Hospital and Solove Research Institute opened in 1990 as the Midwest’s first freestanding cancer hospital and the patient-care component of The Ohio State University Comprehensive Cancer Center. Ranked by U.S. News & World Report as one of the top hospitals in the nation for cancer care, the hospital is one of only 11 DRG-exempt (diagnosis-related-group-exempt) or PPS-exempt (prospective-payment-system-exempt) institutions in the United States. The OSUCCC – James has helped pioneer the transdisciplinary, multimodality approach to cancer treatment and patient care. As a founding member of the National Comprehensive Cancer Network (NCCN), the OSUCCC – James helps establish national guidelines and standards of cancer care. The OSUCCC – James has more than 200 oncologists, each of whom specializes in just one type of cancer. That expert subspecialization leads to more productive integration with cancer research and, ultimately, to better outcomes in patient care. The cancer center also offers a robust clinical trials program; many of these protocols are initiated by OSUCCC – James investigators. Learn more about the OSUCCC – James at cancer.osu.edu.
Currently Enrolling

HCRN-BRE20-468

A Phase II Study of Ribociclib And Endocrine Treatment of Physician’s Choice for Locoregional Recurrent, Resected Hormone Receptor Positive HER2 Negative Breast Cancer (RaPhLRR Study)
Cancer areas:Breast
Fred & Pamela Buffett Cancer Center
New York University Cancer Institute
Orlando Health Cancer Institute
Parkview Research Center
Penn State Cancer Institute
Providence Cancer Institute
Rutgers Cancer Institute of New Jersey
The Ohio State University
Tufts Medical Center
University of Alabama at Birmingham Comprehensive Cancer Center
University of Arizona Cancer Center
University of Illinois Cancer Center
University of Iowa Holden Comprehensive Cancer Center
University of Michigan Health-West
University of Michigan Rogel Cancer Center
University of Virginia Cancer Center
University of Wisconsin Carbone Cancer Center
Currently Enrolling

HCRN-BRE21-516

BRIDGET: Secondary BRain metastases prevention after Isolated intracranial progression on Trastuzumab/Pertuzumab or T-DM1 in patients with aDvanced human epidermal Growth factor receptor 2+ brEast cancer with the addition of Tucatinib
Cancer areas:Breast
Dana-Farber Cancer Institute
Duke Cancer Institute
MD Anderson Cancer Center
Novant Health Oncology Specialists
Providence Cancer Institute
Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine
The Ohio State University
UC San Francisco
University of Michigan Rogel Cancer Center
Currently Enrolling

HCRN-GU22-587

Advanced Renal Cell Cancer Combination ImmunoThErapy Clinical Trial (ARCITECT)
Cancer areas:Kidney
Beth Israel Deaconess Medical Center
Columbia University Irving Medical Center
Dana-Farber Cancer Institute
Georgetown Lombardi Comprehensive Cancer Center
Indiana University Melvin and Bren Simon Comprehensive Cancer Center
John Theurer Cancer Center at Hackensack Meridian Health
Moores Cancer Center at UC San Diego Health
Penn Medicine Abramson Cancer Center
The Ohio State University
UT Southwestern Harold C. Simmons Comprehensive Cancer Center
Weill Cornell Medicine
Winship Cancer Institute of Emory University
Yale Cancer Center
Currently Enrolling

HCRN-LUN21-534

DURABLE: Delayed or Upfront brain RAdiotherapy in treatment naïve lung cancer patients with asymptomatic or minimally symptomatic Brain metastases and rEarrangements
Cancer areas:Lung
Stanford University
The Ohio State University
Currently Enrolling

HCRN-LYM21-544

Phase 2, open label, multicenter study of pacritinib in relapsed/refractory T-cell lymphoproliferative neoplasms
Cancer areas:Lymphoma
City of Hope
The Ohio State University
University of Michigan Rogel Cancer Center
Currently Enrolling

BTCRC-GI21-500

A Phase II Study of Peri-Operative NovoTTF-200T(P) in Combination with Gemcitabine and Nab-Paclitaxel for Resectable Pancreatic Adenocarcinoma: Big Ten Cancer Research Consortium BTCRC-GI21-500
Cancer areas:Pancreatic
The Ohio State University
Currently Enrolling

BTCRC-LUN18-153

A Randomized Phase II Trial of Adjuvant Pembrolizumab Versus Observation Following Curative Resection for Stage I Non-small Cell Lung Cancer (NSCLC) With Primary Tumors Between 1-4 cm
Cancer areas:Lung
Fred & Pamela Buffett Cancer Center
Indiana University Melvin and Bren Simon Comprehensive Cancer Center
Masonic Cancer Center, University of Minnesota
Moffitt Cancer Center
Penn State Cancer Institute
Providence Cancer Institute
Rutgers Cancer Institute of New Jersey
The Ohio State University
University of Illinois Cancer Center
University of Iowa Holden Comprehensive Cancer Center
University of Virginia Cancer Center
Virginia Commonwealth University
Currently Enrolling

BTCRC-LUN20-462

A Randomized, Multi-Cohort Phase II Trial of Temozolomide and Atezolizumab as Second Line Treatment for Small Cell Lung Cancer
Cancer areas:Lung
Indiana University Melvin and Bren Simon Comprehensive Cancer Center
The Ohio State University
University of Illinois Cancer Center
University of Iowa Holden Comprehensive Cancer Center
University of Wisconsin Carbone Cancer Center
Currently Enrolling

BTCRC-LYM20-463

A Single Arm Phase I/II Study of Tazemetostat with Rituximab and Abbreviated Bendamustine in the Frontline Treatment of High Tumor Burden Follicular Lymphoma
Cancer areas:Lymphoma
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Rutgers Cancer Institute of New Jersey
The Ohio State University
University of Illinois Cancer Center
University of Wisconsin Carbone Cancer Center
Enrollment Closed

HCRN-GI16-288

A Phase II Trial of Perioperative CV301 Vaccination in Combination With Nivolumab and Systemic Chemotherapy for Resectable Hepatic-Limited Metastatic Colorectal Cancer HCRN: GI16-288
Cancer areas:Colorectal
Cleveland Clinic Cancer Center
Knight Cancer Institute at Oregon Health & Science University
Rutgers Cancer Institute of New Jersey
Sylvester Comprehensive Cancer Center at the University of Miami
The Ohio State University
University of Kansas Medical Center
Enrollment Closed

BTCRC-LUN18-363

A Phase II Study of Chemo-Immunotherapy Followed by Durvalumab (MEDI4736) and Ceralasertib (AZD6738) in Treatment Naïve Patients With Extensive Stage Small Cell Lung Cancer (ES-SCLC) Big Ten Cancer Research Consortium BTCRC-LUN18-363
Cancer areas:Lung
Indiana University Melvin and Bren Simon Comprehensive Cancer Center
The Ohio State University
University of Illinois Cancer Center
University of Iowa Holden Comprehensive Cancer Center
University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center
Enrollment Closed

BTCRC-LUN19-396

A Phase II Study of Adjuvant Treatment With Cisplatin-based Chemotherapy Plus Concomitant Atezolizumab in Patients With Stage I (Tumors ≥ 4cm), IIA, IIB, and Select IIIA [T3N1, T4N0-1] Resected Non-small Cell Lung Cancer (NSCLC) and the Clearance of Circulating Tumor DNA (ctDNA)
Cancer areas:Lung
Indiana University Melvin and Bren Simon Comprehensive Cancer Center
New York University Cancer Institute
Penn State Cancer Institute
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Rutgers Cancer Institute of New Jersey
Summit Health Cancer Center
The Ohio State University
University of Virginia Cancer Center
University of Wisconsin Carbone Cancer Center