Hoosier Cancer Research Network Translational Research Seminars

Hoosier Cancer Research Network introduced the Translational Research Seminars series in late 2021 to provide opportunities for investigators to present innovative biomarker research and discuss potential collaboration. These seminars are open to all investigators at HCRN member institutions.

Upcoming Translational Research Seminars

Friday, September 30, 2022

TOPIC: Pan-cancer microbiome analyses of blood and tissues reveal cancer type specific ecologies and multi-domain interactions by Greg Sepich-Poore, PhD, of UC San Diego

Historical accounts document the link between cancer and microbes, but their role in diagnosis, prognosis, and therapy has remained underappreciated. Here, Dr. Sepich-Poore will present the two largest analyses to date of cancer-associated bacteria and fungi, respectively, in tissues and blood, covering more than 10,000 patients across 35 cancer types and four international cohorts. Notably, bacterial and fungal compositions are ubiquitous, cancer type specific, and synergistic for creating novel plasma-derived cancer diagnostics, including for stage I cancers.

These results remain true even when accounting for computational and experimental contamination controls or when subsetting blood-related analyses to tumor-identified microbes. Collectively, these findings suggest that a new class of microbiome-based cancer diagnostic tools may provide substantial future value to patients and physicians, and future explorations for their functions may additionally yield novel drug targets for biopharma.

Sign Up for a HCRN Translational Research Seminar

Complete this form if you would like to receive calendar invitations for the HCRN Translational Research Seminars series. Attendees must be covered by an Institutional Participant Agreement (IPA) or Confidential Disclosure Agreement (CDA) with Hoosier Cancer Research Network. HCRN will confirm your coverage and will contact you if a new CDA is required for your participation.

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Past Translational Research Seminars

July 2022

TOPIC: Spatial Profiling in Breast Cancer presented by Ilana Schlam, MD, Tufts Medical Center

April 2022

TOPIC: Genomics Organization for Academic Laboratories (GOAL) presented by Jeremy P. Segal, MD, PhD, The University of Chicago, and Dara Aisner, MD, PhD, University of Colorado Anschutz Medical Campus

December 2021

TOPIC: ctDNA MRD analysis in clinical trials presented by Aadel Chaudhuri, MD, PhD of the Washington University School of Medicine

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