Hoosier Cancer Research Network recognizes the importance of correlating clinical and laboratory data with a goal of identifying factors that are associated with response and/or toxicity to treatment. In 2006, HCRN implemented a biorepository to store and manage correlative samples that are collected as part of HCRN clinical trials. The goal is that analysis performed on these samples will help to identify factors that will predict the best treatment option for each patient.
Correlative research samples collected from consented patients participating in HCRN studies are shipped to our biorepository. The biorepository features two -80C freezers and a -140C mechanical cryogenic freezer. Unstained tissue slides and blocks are also stored ambient in the biorepository. Sample information is logged into an electronic data capture system that records sample type, sample volume, and location in the biorepository. Coded clinical information is also tracked.
Correlative Laboratory Manuals instruct sites on proper collection, processing, and shipping of samples to the HCRN biorepository. Study-specific sample collection kits are provided to sites. These kits include everything needed for the sample collection, including blood collection tubes, pipettes, cryovials, labels, etc. Proper shipping materials are also provided to sites.