Hoosier Cancer Research Network on Facebook

Hoosier Cancer Research Network on Facebook

OnCore Login
Login to Oncore Network

Login to Oncore Network

Hoosier Cancer Research Network on Facebook

Hoosier Cancer Research Network on Facebook

HCRN-GU16-260

Phase II study of front line therapy with nivolumab and salvage nivolumab + ipilimumab in patients with advanced renal cell carcinoma

Status: Closed to Accrual

This study is a prospective phase II trial of nivolumab in 120 treatment-naïve patients with clear cell renal cell carcinoma (ccRCC) and 40 treatment naïve patients with non-clear cell renal cell carcinoma (nccRCC). The primary objective is to determine the progression-free survival (PFS) rate at one year of nivolumab in patients with treatment-naïve ccRCC based on tumor PD-L1 expression.

  • Condition: Advanced renal cell carcinoma
  • Intervention:
    • Drug: Nivolumab
    • Drug: Ipilimumab
  • Phase: Phase II

For full description, see https://clinicaltrials.gov/study/NCT03117309.

Read a news release about this trial.

 
Abstracts/Posters/Presentations:

  • MB Atkins, O Jegede, NB Haas, DF McDermott, MA Bilen, J Hawley, JA Sosman, RS Alter, ER Plimack, MC Ornstein, ME Hurwitz, DJ Peace, S Signoretti, CJ Wu, PJ Catalano, HJ Hammers. Phase II study of nivolumab and salvage nivolumab + ipilimumab in treatment-naïve patients (pts) with advanced non-clear cell renal cell carcinoma (nccRCC) (HCRN GU16-260-Cohort B). Presented as poster discussion at the 2021 American Society of Clinical Oncology Annual Meeting. See abstract.
  • MB Atkins, O Jegede, NB Haas, DF McDermott, MA Bilen, CG Drake, JA Sosman, RS Alter, ER Plimack, BI Rini, ME Hurwitz, DJ Peace, S Signoretti, CJ Wu, PJ Catalano, HJ Hammers. Phase II study of nivolumab and salvage nivolumab + ipilimumab in treatment-naïve patients (pts) with advanced renal cell carcinoma (RCC) (HCRN GU16-260). Presented as an oral abstract at the 2020 American Society of Clinical Oncology Annual Meeting. See abstract.

Study Contact: studies@hoosiercancer.org; (317) 921-2050.