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University of Iowa Holden Comprehensive Cancer Center

200 Hawkins Dr., 7970 JPP Iowa City, IA 52242

Founded in 1980, the Holden Comprehensive Cancer Center at the University of Iowa has been an NCI comprehensive cancer center since 2001. The Center is dedicated to bringing the finest cancer care and research to Iowa and beyond.

Research at Holden is organized into four research programs: cancer genes and pathways, experimental therapeutics, free radical metabolism and imaging, and cancer epidemiology and population science. The Center promotes interactive cancer research, provides health care related to the prevention, detection, and treatment of cancer, and educates cancer professionals and the citizens of Iowa about cancer.

Holden is also organized around specific cancer types through its Multidisciplinary Oncology Groups which include a dozen multidisciplinary teams that are involved in both clinical care and research. The Center enrolls many patients in its active program of early phase clinical trials and also supports clinical and translational research done in collaboration with other cancer centers through efforts including the Iowa/Mayo Lymphoma SPORE, the National Clinical Trials Network and the Big Ten Cancer Research Consortium. Holden also is the only cancer center in the nation with a SPORE grant to study Neuroendocrine tumors.

Additional research is taking place through the efforts of multidisciplinary teams involved in cancer prevention, cancer and obesity, stem cell transplantation and molecular oncology. Holden has an active molecular oncology program that includes a Molecular Tumor Board and a Molecular Pathology team that is CLIA certified and CAP accredited and conducts multigene cancer hotspot mutation testing with next generation sequencing.

The Center supports 11 shared research resources that provide support to cancer investigators exploring molecular and cellular aspects of cancer, clinical trials and population studies. Holden has established prospective registries linked to biospecimens for select cancer types know as the Molecular Epidemiology Resources. Over 4000 subjects have been enrolled in these registries.

Website: Holden Comprehensive Cancer Center at the University of Iowa

Janelle Born

Trials at this location:


A Phase II Study of Ribociclib And Endocrine Treatment of Physician’s Choice for Locoregional Recurrent, Resected Hormone Receptor Positive HER2 Negative Breast Cancer (RaPhLRR Study)

Status: Open to Accrual
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PhAse I/II StuDy of Modern ImmunotherApy in BCG-RelaPsing UroThelial Carcinoma of the BLADDER – (ADAPT-BLADDER) HCRN GU16-243

Status: Open to Accrual
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Single Arm Phase II Study of Ipilimumab and Nivolumab as Adjuvant Therapy for Resected Mucosal Melanoma (SALVO Study). HCRN: MEL16-252

Status: Closed to Accrual
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