Researchers participating in the Hoosier Cancer Research Network GU16-260 study have published a correlative analysis in Cancer Discovery. The analysis, led by David A. Braun, MD, PhD, of Yale Cancer Center; Catherine J. Wu, MD, of the Dana-Farber Cancer Institute; and Michael B. Atkins, MD, of Georgetown Lombardi Comprehensive Cancer Center, found that the presence of tertiary lymphoid structures and exhausted tissue-resident T cells determines clinical response to PD-1 blockade in renal cell carcinoma.

Congratulations to all co-authors and study teams whose hard work led to this publication!

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Hoosier Cancer Research Network (HCRN) is set to participate in ASCO GU 2025 in San Francisco from February 13-15, 2025, with HCRN-GU16-243 being presented as a Rapid Oral Abstract, and several other studies as poster presentations.

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A Hoosier Cancer Research Network study, HCRN-LUN21-497, titled, “Results from a phase II study of GT103 in combination with pembrolizumab in refractory, metastatic non-small cell lung cancer,” was presented at SITC 2024 by Jeffrey Clarke, MD, of Duke University.

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HCRN-GI23-643, titled, “Randomized Trial of Regorafenib in Combination with Pembrolizumab or Pembrolizumab Monotherapy for Patients with MSI-H Colorectal Cancer,” will be presented as a Trials in Progress poster at the American Society of Clinical Oncology® (ASCO) Gastrointestinal Cancers Symposium 2025 in San Francisco. This study is led by Ibrahim Sahin, MD, of UPMC Hillman Cancer Center.

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A correlative study related to the Hoosier Cancer Research Network (HCRN) clinical trial, HCRN-GU16-243, titled, “A Phase 1 Trial of Durvalumab in Combination with Bacillus Calmette-Guerin (BCG) or External Beam Radiation Therapy in Patients with BCG-unresponsive Non-muscle-Invasive Bladder Cancer: The Hoosier Cancer Research Network GU16-243 ADAPT-BLADDER Study,” was presented at SUO 2024 by Noah Hahn, MD, of Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center.  

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A Hoosier Cancer Research Network (HCRN) study, HCRN-LUN18-335, led by Xiuning Le, MD, PhD, of the University of Texas MD Anderson Cancer Center, was published in the Journal of Clinical Oncology on October 8, 2024. The article is titled, “A Multicenter Open-Label Randomized Phase II Study of Osimertinib With and Without Ramucirumab in Tyrosine Kinase Inhibitor–Naïve EGFR-Mutant Metastatic Non–Small Cell Lung Cancer (RAMOSE trial).” Congratulations to all co-authors and study teams whose hard work led to this publication!

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Hoosier Cancer Research Network (HCRN) is currently seeking a full-time clinical research monitor. Bachelor’s degree in life sciences or a related field, minimum of two years’ experience in clinical research (oncology preferred), familiarity with GCP, HIPAA, medical terminology, electronic medical records, and research compliance required. 

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Hoosier Cancer Research Network congratulates Rita Assi, MD, on her election as the President-Elect of the Indiana Oncology Society 2024-2026 Board of Directors. Dr. Assi is a board member of HCRN and is assistant professor of clinical medicine at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center.

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Hoosier Cancer Research Network (HCRN) recently joined two of our visionary founders, Patrick J. Loehrer, MD, and William B. Fisher, MD, as they shared stories spanning their 40 years of partnership through HCRN, formerly known as Hoosier Oncology Group, or affectionately, the “HOG.”

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A Hoosier Cancer Research Network trial, HCRN-LUN18-357, titled “P1.08D.03 Induction Durvalumab Followed by Chemoradiation and Consolidation Durvalumab for Stage III Non-Small Cell Lung Cancer (NSCLC)” has been accepted as a poster presentation and will be presented at the World Conference on Lung Cancer Meeting on September 8, 2024 from 12:00 pm-2:00 pm.

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Hoosier Cancer Research Network is happy to celebrate the research accomplishments of our members over the past year. Congratulations to all researchers and study teams whose hard work produced 23 journal manuscripts and meeting abstracts between July 1, 2023, and June 30, 2024!

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A Hoosier Cancer Research Network trial, HCRN-GU22-587, titled, “Advanced Renel Cell Cancer Combination Immunotherapy Clinical Trial,” was presented this week at the Kidney Cancer Research Summit (KCRS). Michael Serzan, MD (pictured right), of Dana-Farber Cancer Institute, presented the study as a trial in progress.

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Hoosier Cancer Research Network (HCRN) is proud to share that an article written by former HCRN team members, Tim Breen and Adelai Neal, titled, “The Endpoints Dataset: A Quality Control Method for Review and Analysis of Critical Efficacy Endpoints Data,” has been published in the Spring Issue 2024 of the Journal of the Society for Clinical Data Management (JSCDM).

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Brian Stemme, Hoosier Cancer Research Network’s (HCRN) chief executive officer, was recently featured on Pathfinder, a Purdue Life Sciences podcast with Dr. Thomas G. Sors from Purdue Institute of Inflammation, Immunology and Infectious Disease (PI4D). Stemme shared insights on his career journey, why Indiana is a top spot for life sciences and HCRN’s impactful work.

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Hoosier Cancer Research Network congratulates Dr. Robin Zon on assuming her new role as president of the American Society of Clinical Oncology. Dr. Zon served as HCRN’s vice chair from 2006-2009, and as chief community officer from 2009-2010.  

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Chief Executive Officer of Hoosier Cancer Research Network, Brian Stemme, authored an article on Inside Indiana Business titled, “Belief-driven employees seek organizations that make a difference,” published May 24, 2024.  

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Hoosier Cancer Research Network is excited to share that Reps for Research 2024 has raised $3,060, bringing our 7-year cumulative total to more than $26,000.

Reps for Research took place on March 3, 2024, as fundraiser for Hoosier Cancer Research Network (HCRN) led by Christopher A. Fausel, chairman of HCRN’s board of directors and oncology precision genomics pharmacist at the IU Simon Comprehensive Cancer Center. The event included Fausel’s participation in the Arnold Sports Festival Pump & Run 5K in Columbus, Ohio.

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Co-chairs of the HCRN Lymphoma Working Group, Jonathan B. Cohen, MD, Natalie Galanina, MD, and Natalie Grover, MD, were driven by science and the influence of strong mentors early in their careers. It’s also why lymphoma is a focus of their work as they see great opportunities to make an impact through the WG collaboration.

Dr. Cohen is associate professor in the Department of Hematology and Medical Oncology, Emory University School of Medicine, and co-director of the Lymphoma Program at Winship Cancer Institute of Emory University; Dr. Galanina, is associate professor of medicine at the University of Pittsburgh Medical Center; and Dr. Grover is associate professor of medicine, clinical director, Cellular Therapy Program, and leader, Cell Therapy POD at the University of North Carolina School of Medicine. Read More

Hoosier Cancer Research Network is excited to announce that Reps for Research is returning March 3, 2024, after a three-year hiatus.

Reps for Research is a fundraiser for Hoosier Cancer Research Network (HCRN) that is led by Christopher A. Fausel, chairman of HCRN’s board of directors and oncology precision genomics pharmacist at the IU Simon Comprehensive Cancer Center. The event includes Fausel’s participation in the Arnold Sports Festival Pump & Run 5K in Columbus, Ohio.

Fausel invites pledges in support of HCRN for every bench press “rep” he completes during the event, with a maximum of 30 “reps.” Donations received will directly support investigator-initiated research, which is central to HCRN’s vision and mission.

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