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UC-GENOME: Urothelial Cancer-GENOmic Analysis to iMprove Patient Outcomes and rEsearch: Hoosier Cancer Research Network GU15-217

Status: Closed to Accrual

This comprehensive genomic analysis and biospecimen repository research study incorporates Next Generation Sequencing (NGS) of archival tumor tissue from 200 subjects with metastatic urothelial cancer in support of several parallel goals. The immediate goal involves generation of a comprehensive report identifying subject specific genetic mutations and/or alterations based on NGS. Once NGS is complete and DNA and RNA extracted from the specimens, additional tumor tissue and blood will be stored for future research. Long-term, the goal of this endeavor is to support collaborative translational research projects in metastatic urothelial cancer by allowing investigators to interrogate abstracted coded clinical data linked to data from any biospecimen studies.

Learn more:

  • Study Type: Observational
  • Condition: Urothelial carcinoma of the bladder, renal pelvis, ureter, or urethra
  • Intervention:
    • Other: Biospecimen Collection

For full description, see https://clinicaltrials.gov/study/NCT02643043.

Read a news release about this trial.


  • JS Damrauer, J Klomp, W Beck, M Zhou, E Plimack, M Galsky, P Grivas, N Hahn, P O’Donnell, G Iyer, DI Quinn, KA Hoadley, WY Kim, MI Milowsky. Urothelial cancer-GENOmic analysis to improve patient outcomes and research (UC-GENOME): a bladder cancer advocacy network (BCAN) led collaborative research study. Presented as a poster at the American Association for Cancer Research (AACR) 2021 Annual Meeting. See abstract.

Study Contact: studies@hoosiercancer.org; (317) 921-2050.